{"id":821,"date":"2024-06-09T19:41:54","date_gmt":"2024-06-09T17:41:54","guid":{"rendered":"https:\/\/kampanj.expressen.se\/hjarnfonden\/?p=821"},"modified":"2024-06-11T14:00:39","modified_gmt":"2024-06-11T12:00:39","slug":"forskning-i-framkant-ger-hopp-for-framtiden","status":"publish","type":"post","link":"https:\/\/kampanj.expressen.se\/hjarnfonden\/forskning-i-framkant-ger-hopp-for-framtiden\/","title":{"rendered":"Forskning i framkant ger hopp f\u00f6r framtiden"},"content":{"rendered":"

[et_pb_section fb_built=”1″ disabled_on=”off|off|off” admin_label=”HERO” _builder_version=”4.25.1″ _module_preset=”default” use_background_color_gradient=”on” background_color_gradient_stops=”rgba(0,0,0,0) 55%|rgba(0,0,0,0.47) 100%” background_color_gradient_overlays_image=”on” background_color_gradient_start=”rgba(0,0,0,0)” background_color_gradient_start_position=”31%” background_color_gradient_end=”rgba(0,0,0,0.65)” background_image=”https:\/\/kampanj.expressen.se\/hjarnfonden\/wp-content\/uploads\/2024\/06\/eva-hedlund-1.jpg” background_position=”top_center” background_vertical_offset=”24%” background_enable_video_mp4=”off” background_video_width=”100%” min_height=”650px” min_height_tablet=”500px” min_height_phone=”350px” min_height_last_edited=”on|phone” height=”100vh” max_height=”1000px” max_height_tablet=”900px” max_height_phone=”600px” max_height_last_edited=”on|tablet” background_last_edited=”off|desktop” background_image_tablet=”https:\/\/kampanj.expressen.se\/hjarnfonden\/wp-content\/uploads\/2024\/05\/hf-petra-1-small.jpg” background_image_phone=”https:\/\/kampanj.expressen.se\/hjarnfonden\/wp-content\/uploads\/2024\/05\/hf-petra-1-small.jpg” background_enable_image_tablet=”on” background_enable_image_phone=”on” background_position_tablet=”center” background_position_phone=”center” background_enable_video_mp4_phone=”off” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_row _builder_version=”4.25.0″ _module_preset=”default” positioning=”absolute” position_origin_a=”bottom_center” position_origin_r=”bottom_right” vertical_offset=”20px” vertical_offset_tablet=”” vertical_offset_phone=”2rem” vertical_offset_last_edited=”on|desktop” width_tablet=”80%” width_phone=”90%” width_last_edited=”on|phone” max_width=”900px” custom_padding=”||0px||false|false” locked=”off” global_colors_info=”{}” width__hover_enabled=”off|desktop” theme_builder_area=”post_content”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_text content_tablet=”<\/p>\n

D\u00e4rf\u00f6r p\u00e5verkar k\u00f6net
n\u00e4r du f\u00e5r din diagnos<\/h1>\n

” content_phone=”<\/p>\n

D\u00e4rf\u00f6r p\u00e5verkar k\u00f6net n\u00e4r du f\u00e5r din diagnos<\/h1>\n

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Forskning i framkant ger hopp f\u00f6r framtiden<\/h1>\n

[\/et_pb_text][et_pb_icon font_icon=”3||divi||400″ icon_color=”#FFFFFF” icon_width=”55px” icon_width_tablet=”55px” icon_width_phone=”50px” icon_width_last_edited=”on|phone” _builder_version=”4.25.0″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][\/et_pb_icon][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.25.1″ _module_preset=”default” positioning=”absolute” position_origin_a=”bottom_right” vertical_offset=”10px” horizontal_offset=”10px” max_width=”250px” custom_margin=”||0px||false|false” custom_padding=”||0px||false|false” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”4_4″ _builder_version=”4.25.1″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_text _builder_version=”4.25.1″ _module_preset=”default” text_text_color=”#FFFFFF” text_font_size=”16px” text_orientation=”right” text_font_size_tablet=”16px” text_font_size_phone=”14px” text_font_size_last_edited=”on|phone” text_text_shadow_style=”preset3″ global_colors_info=”{}” theme_builder_area=”post_content”]Foto: S\u00f6ren Andersson[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ custom_padding_last_edited=”on|tablet” admin_label=”Artikel\/text 1″ _builder_version=”4.19.0″ _module_preset=”default” background_color=”#FFFFFF” custom_padding=”50px||50px||true|false” custom_padding_tablet=”50px||50px||true|false” custom_padding_phone=”40px||40px||true|false” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_row custom_padding_last_edited=”off|phone” _builder_version=”4.25.0″ _module_preset=”default” background_enable_color=”off” width_tablet=”80%” width_phone=”90%” width_last_edited=”on|phone” max_width=”640px” max_width_last_edited=”off|desktop” module_alignment=”center” custom_margin=”||||false|false” custom_padding=”0px|0px|0px|0px|false|true” custom_padding_tablet=”|60px||60px|true|true” custom_padding_phone=”|30px||30px|true|true” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_text _builder_version=”4.25.1″ _module_preset=”default” text_font=”Arial|600|||||||” text_text_color=”#141414″ text_font_size=”18px” text_line_height=”1.5em” header_3_font=”di-benton-bold||||||||” header_3_text_color=”#222222″ header_3_font_size=”19px” header_3_line_height=”1.5em” custom_padding=”||22px||false|false” custom_padding_tablet=”||22px||false|false” custom_padding_last_edited=”off|desktop” text_font_size_phone=”18px” text_font_size_last_edited=”off|desktop” text_line_height_tablet=”” text_line_height_phone=”” text_line_height_last_edited=”on|desktop” header_3_font_size_tablet=”” header_3_font_size_phone=”18px” header_3_font_size_last_edited=”on|phone” border_width_bottom=”1px” border_color_bottom=”rgba(0,0,0,0.15)” global_colors_info=”{}” theme_builder_area=”post_content”]<\/p>\n

Forskningen kring den obotliga sjukdomen ALS har tagit j\u00e4ttekliv de senaste \u00e5ren. P\u00e5 Stockholms universitet forskar man p\u00e5 olika typer av nervceller, f\u00f6r att b\u00e4ttre f\u00f6rst\u00e5 hur ALS uppkommer.<\/span><\/p>\n

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\u2013 Det har skett oerh\u00f6rda framsteg sedan jag b\u00f6rjade forska p\u00e5 ALS f\u00f6r drygt 20 \u00e5r sedan, konstaterar Eva Hedlund, professor i neurokemi vid Stockholms universitet.<\/p>\n

\u2013 Tidigare trodde man att ALS mest berodde p\u00e5 milj\u00f6faktorer. Nu vet vi vilka olika genmutationer som orsakar familj\u00e4rt ned\u00e4rvd ALS och man har kunnat b\u00f6rja utveckla riktade l\u00e4kemedel.<\/p>\n

Ocks\u00e5 i de fall d\u00e4r ingen i familjen tidigare har drabbats av sjukdomen vet man idag att en hel del kan f\u00f6rklaras med genetik, \u00e4ven om bilden \u00e4r komplex.<\/p>\n

Det som sker n\u00e4r n\u00e5gon insjuknar i ALS \u00e4r att nervcellerna som skickar ut signaler till musklerna, de s\u00e5 kallade motorneuronerna, f\u00f6rlorar kontakten med musklerna. Det leder i sin tur till att musklerna f\u00f6rsvagas och f\u00f6rtvinar.<\/p>\n

Varf\u00f6r det sker \u00e4r ett av de omr\u00e5den som Eva Hedlund och hennes forskargrupp arbetar med att f\u00f6rs\u00f6ka f\u00f6rst\u00e5.<\/p>\n

\u2013 I v\u00e5rt labb har vi d\u00e4rf\u00f6r utvecklat nya tekniker f\u00f6r att titta p\u00e5 hela nervcellen, inte bara k\u00e4rnan, f\u00f6rklarar hon.<\/p>\n

Sj\u00e4lva cellk\u00e4rnan utg\u00f6r n\u00e4mligen en ytterst liten del av nervcellen. Eva Hedlund j\u00e4mf\u00f6r med ett isberg, d\u00e4r endast en f\u00f6rsvinnande liten del syns ovanf\u00f6r vattenytan: 98 procent av nervcellen best\u00e5r i sj\u00e4lva verket av ett l\u00e5ngt utskott, axonet, som utg\u00f6r kopplingen mellan nervcellen och muskeln.<\/p>\n

EXTERN L\u00c4NK: L\u00e4s mer om ALS<\/strong><\/a><\/p>\n

[\/et_pb_text][et_pb_image src=”https:\/\/kampanj.expressen.se\/hjarnfonden\/wp-content\/uploads\/2024\/06\/eva-hedlund-3.jpg” title_text=”eva-hedlund-3″ _builder_version=”4.25.1″ _module_preset=”default” custom_margin=”27px||10px||false|false” custom_padding=”0px||0px||true|false” animation_style=”fade” border_radii=”on|16px|16px|16px|16px” global_colors_info=”{}” theme_builder_area=”post_content”][\/et_pb_image][et_pb_text _builder_version=”4.25.1″ _module_preset=”default” text_text_color=”#969696″ text_font_size=”16px” text_line_height=”1.3em” custom_margin=”0px||27px||false|false” custom_padding=”0px||0px||true|false” global_colors_info=”{}” theme_builder_area=”post_content”]Foto: Juliana Wolf Garcindo[\/et_pb_text][et_pb_text _builder_version=”4.25.1″ _module_preset=”default” text_font=”Arial||||||||” text_text_color=”#141414″ text_font_size=”18px” text_line_height=”1.5em” header_font_size=”24px” header_2_font=”Siri Expressen||||||||” header_2_text_color=”#141414″ custom_padding=”0px||||false|false” header_2_font_size_tablet=”” header_2_font_size_phone=”23px” header_2_font_size_last_edited=”on|phone” border_color_bottom=”rgba(0,0,0,0.15)” global_colors_info=”{}” theme_builder_area=”post_content”]<\/p>\n

Helt f\u00f6rlamad \u2013 f\u00f6rutom \u00f6gonmuskulaturen<\/h2>\n

Forskarlagets studier har visat att det h\u00e4nder v\u00e4ldigt olika saker i sj\u00e4lva cellk\u00e4rnan och i utskottet n\u00e4r en genmutation orsakar ALS.<\/p>\n

\u2013 Vi unders\u00f6ker helt enkelt vad som h\u00e4nder n\u00e4r man introducerar genmutationer som orsakar ALS i cellen. Sedan g\u00e5r vi in och ser om man kan r\u00e4dda situationen. Det h\u00e4r \u00e4r en forskning som vi \u00e4r mitt uppe i, men som vi hoppas slutf\u00f6ra inom n\u00e5got \u00e5r, ber\u00e4ttar hon.<\/p>\n

Sedan en l\u00e4ngre tid tillbaka studerar hennes forskargrupp ocks\u00e5 de nervceller som styr v\u00e5ra \u00f6gons r\u00f6relser, s\u00e5 kallade okulomotoriska motorneuroner. Den som insjuknar i ALS blir s\u00e5 sm\u00e5ningom helt f\u00f6rlamad \u2013 f\u00f6rutom vad g\u00e4ller \u00f6gonmuskulaturen. Just de h\u00e4r nervcellerna \u00e4r betydligt mer motst\u00e5ndskraftiga \u00e4n andra och forskarna vet \u00e4nnu inte riktigt varf\u00f6r.<\/p>\n

\u2013 Vi har gjort studier d\u00e4r vi introducerat gener som endast \u00e4r aktiva i de okulomotoriska motorneuronerna till mer k\u00e4nsliga motorneuroner i ryggm\u00e4rgen, s\u00e5 kallad genterapi, och f\u00e5tt dem att klara sig b\u00e4ttre. Motorneuronerna har d\u00e5 till och med lyckats skapa nya kontakter med musklerna under sjukdomsf\u00f6rloppet.<\/p>\n

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Eva Hedlund, professor i neurokemi vid Stockholms universitet.
Foto: S\u00f6ren Andersson<\/p>\n

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Mer effektiva mediciner och botemedel<\/h2>\n

Hittills har studierna gjorts i laboratorium. N\u00e4sta steg \u00e4r att hitta finansiering f\u00f6r att genomf\u00f6ra l\u00e5ngtidsstudier p\u00e5 friska djur, f\u00f6r att utr\u00f6na om det blir n\u00e5gra negativa effekter \u00f6ver tid. D\u00e4refter \u00e4r f\u00f6rhoppningen att kunna g\u00e5 vidare till kliniska studier, p\u00e5 m\u00e4nniskor.<\/p>\n

Eva Hedlund och hennes team har flera g\u00e5nger f\u00e5tt forskningsmedel fr\u00e5n Hj\u00e4rnfonden f\u00f6r sin forskning kring ALS.<\/p>\n

\u2013 Forskningsanslag \u00e4r avg\u00f6rande f\u00f6r att forskning ska kunna genomf\u00f6ras och stiftelser som Hj\u00e4rnfonden \u00e4r oerh\u00f6rt viktiga \u2013 i Sverige finns inte s\u00e5 mycket \u00f6ronm\u00e4rkta pengar f\u00f6r forskning kring just sjukdomar i hj\u00e4rnan.<\/p>\n

Hon \u00e4r hoppfull \u00f6ver att man inom \u00f6versk\u00e5dlig framtid ska f\u00f6rst\u00e5 mer om faktorerna bakom ALS och d\u00e4rmed ocks\u00e5 kunna hitta mer effektiva bromsmediciner och botemedel:<\/p>\n

\u2013 Det p\u00e5g\u00e5r s\u00e5 otroligt m\u00e5nga samarbeten mellan olika forskare. Vi jobbar tillsammans med m\u00e4nniskor \u00f6ver hela v\u00e4rlden f\u00f6r att l\u00f6sa g\u00e5tan kring den h\u00e4r hemska sjukdomen.<\/p>\n

EXTERN L\u00c4NK: St\u00f6d forskningen om ALS och andra av hj\u00e4rnans sjukdomar och diagnoser. Bli m\u00e5nadsgivare hos Hj\u00e4rnfonden.<\/strong><\/a><\/p>\n

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Hj\u00e4rnfonden<\/h3>\n

Hj\u00e4rnfonden arbetar f\u00f6r ett samh\u00e4lle d\u00e4r alla hj\u00e4rnor n\u00e5r sin fulla potential, fria fr\u00e5n sjukdomar. Det m\u00f6jligg\u00f6rs genom insamling och finansiering av hj\u00e4rnforskning, samt kunskapsspridning och opinionsbildning. De senaste 25 \u00e5ren har Hj\u00e4rnfonden, tack vare g\u00e5vor fr\u00e5n privatpersoner, f\u00f6retag och testamenten, delat ut n\u00e4ra en miljard kronor till olika forskningsprojekt.<\/p>\n

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Vad \u00e4r ALS?<\/h3>\n

ALS (amyotrofisk lateralskleros) \u00e4r namnet p\u00e5 en grupp neurodegenerativa sjukdomar d\u00e4r nervceller i hj\u00e4rnan, hj\u00e4rnstammen och ryggm\u00e4rgen d\u00f6r. Det leder i sin tur till muskelf\u00f6rtvining och f\u00f6rlamning. Forskarna uppskattar att drygt 400 personer \u00e5rligen insjuknar i ALS i Sverige. Det \u00e4r dubbelt s\u00e5 vanligt hos m\u00e4n som hos kvinnor. De flesta som f\u00e5r ALS insjuknar mellan 50\u201370 \u00e5rs \u00e5lder. Man kan i dag inte bli frisk fr\u00e5n ALS, men det finns l\u00e4kemedel som bromsar sjukdomsf\u00f6rloppet n\u00e5got och som kan lindra vissa symtom. Forskning p\u00e5g\u00e5r, men \u00e4nnu \u00e5terst\u00e5r mycket f\u00f6r att l\u00f6sa g\u00e5tan med ALS.[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"

Forskning i framkant ger hopp f\u00f6r framtidenFoto: S\u00f6ren AnderssonForskningen kring den obotliga sjukdomen ALS har tagit j\u00e4ttekliv de senaste \u00e5ren. P\u00e5 Stockholms universitet forskar man p\u00e5 olika typer av nervceller, f\u00f6r att b\u00e4ttre f\u00f6rst\u00e5 hur ALS uppkommer.\u2013 Det har skett oerh\u00f6rda framsteg sedan jag b\u00f6rjade forska p\u00e5 ALS f\u00f6r drygt 20 \u00e5r sedan, konstaterar Eva […]<\/p>\n","protected":false},"author":1,"featured_media":776,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[1],"tags":[],"class_list":["post-821","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-okategoriserade"],"_links":{"self":[{"href":"https:\/\/kampanj.expressen.se\/hjarnfonden\/wp-json\/wp\/v2\/posts\/821","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kampanj.expressen.se\/hjarnfonden\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kampanj.expressen.se\/hjarnfonden\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kampanj.expressen.se\/hjarnfonden\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kampanj.expressen.se\/hjarnfonden\/wp-json\/wp\/v2\/comments?post=821"}],"version-history":[{"count":15,"href":"https:\/\/kampanj.expressen.se\/hjarnfonden\/wp-json\/wp\/v2\/posts\/821\/revisions"}],"predecessor-version":[{"id":857,"href":"https:\/\/kampanj.expressen.se\/hjarnfonden\/wp-json\/wp\/v2\/posts\/821\/revisions\/857"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/kampanj.expressen.se\/hjarnfonden\/wp-json\/wp\/v2\/media\/776"}],"wp:attachment":[{"href":"https:\/\/kampanj.expressen.se\/hjarnfonden\/wp-json\/wp\/v2\/media?parent=821"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kampanj.expressen.se\/hjarnfonden\/wp-json\/wp\/v2\/categories?post=821"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kampanj.expressen.se\/hjarnfonden\/wp-json\/wp\/v2\/tags?post=821"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}